2,3,5-Tri-O-benzyl-D-ribonolactone CAS 55094-52-5 Remdesivir Intermediate COVID-19

Short Description:

Name: 2,3,5-Tri-O-benzyl-D-ribonolactone

Synonyms: 2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone 

CAS: 55094-52-5

Appearance: White to Almost White Powder

Purity: ≥99.0%

Intermediate of Remdesivir (CAS 1809249-37-3) COVID-19

High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com


Product Detail

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Description:

Chemical Properties:

Chemical Name 2,3,5-Tri-O-benzyl-D-ribonolactone
Synonyms 2,3,5-Tri-O-Benzyl-D-Ribono-1,4-Lactone; Remdesivir Intermediate 
CAS Number 55094-52-5
CAT Number RF-PI301
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C26H26O5
Molecular Weight 418.49
Melting Point 54.0-55.0℃
Storage Condition Room Temperature
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance Yellowish or White Solid 
Solubility Soluble in CH2Cl2 and Insoluble in H2O
NMR and MS Should Comply
Identification IR and TLC
Moisture  ≤1.0%
Residue on Ignition ≤0.50%
Any Individual Impurity ≤0.50%
Heavy Metals ≤50ppm
HPLC (210nm) ≥99.0% 
HPLC (ELSD) ≥99.0% 
Test Standard Enterprise Standard
Usage Intermediate of Remdesivir (CAS 1809249-37-3) 

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

Application:

2,3,5-Tri-O-benzyl-D-ribonolactone (CAS 55094-52-5) is a Remdesivir intermediate. Remdesivir (CAS 1809249-37-3) is a novel antiviral drug in the class of nucleotide analogs, used in treatment of COVID-19. Remdesivir (GS-5734) is a novel antiviral nucleoside analogue that inhibits murine hepatitis virus (MHV) with similar EC50 as SARS-CoV and MERS-CoV. Coronaviruses (CoVs) are positive-sense, single-stranded RNA viruses that infect a wide range of animal hosts. In humans, CoVs were recognized as typically causing colds and pneumonia until the emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 from zoonotic sources. Remdesivir is the monophosphoramidate prodrug of the C-adenosine nucleoside analogue GS-441524. In delayed brain tumor (DBT) cells infected with MHV, GS-5734 inhibited MHV more potently than GS-441524, with a GS-5734 EC50 of 0.03 M. Furthermore, EC50 values were determined after treatment with GS-441524 and GS-5734 in SARS-CoV- and MERS-CoV-infected primary human airway epithelial cell (HAE) cultures.

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